Abstracts
- 09/01/2012 - V. A. Huynh-Thu
- 09/01/2012 - R. Küffner
- 09/01/2012 - C. Ambroise
- 16/09/2011 - M. Bunster
- 27/04/2011 - P. Meyer
- 06/04/2011 - D. Débois
- 30/03/2011 - J. Wouters
- 28/01/2011 - J.-C. Lambert
- 13/12/2010 - J. Giard
- 17/11/2010 - B. Charloteaux
- 12/05/2010 - P. Soumillion
- 30/04/2010 - J.-P. Vert
- 14/04/2010 - X. Tordoir
- 24/03/2010 - J.C. Voegel
- 17/03/2010 - A. Turtoi
- 24/02/2010 - L. Palmeira
- 27/01/2010 - D. Devos
- 09/12/2009 - F. Heuze
- 25/11/2009 - L. Geris
- 19/11/2009 - V. Gabelica
- 14/10/2009 - G. Zocchi
- 30/09/2009 - K. Van Steen
- 12/06/2009 - D. Gianola
- 05/06/2009 - F. J. Theis
- 02/06/2009 - M. Babu
- 07/05/2009 - J. Eyzaguirre
- 22/04/2009 - E. Bullinger
- 08/04/2009 - F. Francis
- 04/03/2009 - Kick-off
Multilayer polyelectrolyte films and their "bio" functionalization
Jean-Claude Voegel
Date and place: Wednesday March, 24th 12:30 at E50 (B35)
Biomaterial surface modification became a major issue in the last decade in particular with the further objective to render the surface bioactive . The surface coating by the “layer by layer” technology in order to build polyelectrolyte multilayers constitutes an easy way to reach such objectives. Films can be built using synthetic or natural polyelectrolytes with a thickness that increases linearly or exponentially in thickness or for deposited material. Build ups can be realized easily by dipping alternately the solid surface in polyanion or polycation solutions. An alternative more rapid way concerns a spraying of the solutions also alternately or simultaneously. Biofunctionalisation of the architectures can be achieved via peptides, drugs, proteins or DNA, chemically bound to polyelectrolytes, adsorbed or embedded . The resulting PEM films, have been shown to retain their biological activities. The access of the cells can be tuned finely in time by varying the depth of embedding, or by using blended polyelectrolyte solutions of degradable or nonedegradable polyelectrolytes.
More sophisticated architectures can be obtained by alternating domains constituted by linear growing films “ barriers “ separating “ reservoirs “ constituted by exponentially growing films. In a comparable manner stabilized liposomes can be embedded in films. Such liposomes can also be filled by active compounds and be used as nanoreactors. The deposition of reservoirs separated by barriers onto silicone sheets constitutes a way to apply a lateral stretch on the system. The difference of elasticity of both film parts leads to the formation of nanopores with the possibility to release reagents or initiate their diffusion from one reservoir to another.
It is also possible to construct more sophisticated architectures using functionalized multilayered films deposited onto cell sheets and build by spraying the different elements. In such architectures cells remain viable and tuned cellular signalization can be initiated . This strategy is aimed to tissue engineering in particular for the cartilage and the blood vessel reconstruction. The different aspects will be described and developed in the conference.