Abstracts
- 09/01/2012 - V. A. Huynh-Thu
- 09/01/2012 - R. Küffner
- 09/01/2012 - C. Ambroise
- 16/09/2011 - M. Bunster
- 27/04/2011 - P. Meyer
- 06/04/2011 - D. Débois
- 30/03/2011 - J. Wouters
- 28/01/2011 - J.-C. Lambert
- 13/12/2010 - J. Giard
- 17/11/2010 - B. Charloteaux
- 12/05/2010 - P. Soumillion
- 30/04/2010 - J.-P. Vert
- 14/04/2010 - X. Tordoir
- 24/03/2010 - J.C. Voegel
- 17/03/2010 - A. Turtoi
- 24/02/2010 - L. Palmeira
- 27/01/2010 - D. Devos
- 09/12/2009 - F. Heuze
- 25/11/2009 - L. Geris
- 19/11/2009 - V. Gabelica
- 14/10/2009 - G. Zocchi
- 30/09/2009 - K. Van Steen
- 12/06/2009 - D. Gianola
- 05/06/2009 - F. J. Theis
- 02/06/2009 - M. Babu
- 07/05/2009 - J. Eyzaguirre
- 22/04/2009 - E. Bullinger
- 08/04/2009 - F. Francis
- 04/03/2009 - Kick-off
Multi-scale modeling of bone regeneration
Liesbet Geris
Date and place: Wednesday November, 25th 12:30 at amphi Welsh (CHU, B35)
Fracture healing is a complex process involving the actions and interactions of many cells and proteins. Despite the extensive body of literature on bone regeneration, many questions remain on e.g. the regulatory mechanisms and potential treatment strategies of impaired regeneration cases. The presented work aims at addressing these issues by means of mathematical modeling. A mathematical model was developed encompassing key aspects of the bone regeneration process such as intramembranous and endochondral ossification, angiogenesis and the coupling of these processes with mechanical loading. The results obtained with this model were corroborated both qualitatively and quantitatively by comparison with experimental data for normal fracture healing set-ups. Afterwards, cases of impaired fracture healing were simulated and experimentally testable therapeutic strategies were designed. A first pilot experiment implementing the designed protocol showed promising results. Furthermore, the model was applied to test various hypotheses concerning the nature of the mechanical stimulus influencing the healing process, and the most important cellular processes influenced by mechanical loading. During the first part of the presentations examples will be shown of all of the aforementioned model applications.
In the second part of the presentation mathematical models of bone regeneration processes at cell and protein level will be discussed. An individual cell based model was developed to be able to take into account the intercellular forces, the influence of external signals and cell cycle events in a more mechanistic manner. Additionally, intracellular signaling was investigated by means of gene/protein networks. A first example looking into the interaction between Bone Morphogenetic Protein and Wnt and their combined effect on the osteochondrogenic differentiation of mesenchymal stem cells will be presented.