Abstracts
- 09/01/2012 - V. A. Huynh-Thu
- 09/01/2012 - R. Küffner
- 09/01/2012 - C. Ambroise
- 16/09/2011 - M. Bunster
- 27/04/2011 - P. Meyer
- 06/04/2011 - D. Débois
- 30/03/2011 - J. Wouters
- 28/01/2011 - J.-C. Lambert
- 13/12/2010 - J. Giard
- 17/11/2010 - B. Charloteaux
- 12/05/2010 - P. Soumillion
- 30/04/2010 - J.-P. Vert
- 14/04/2010 - X. Tordoir
- 24/03/2010 - J.C. Voegel
- 17/03/2010 - A. Turtoi
- 24/02/2010 - L. Palmeira
- 27/01/2010 - D. Devos
- 09/12/2009 - F. Heuze
- 25/11/2009 - L. Geris
- 19/11/2009 - V. Gabelica
- 14/10/2009 - G. Zocchi
- 30/09/2009 - K. Van Steen
- 12/06/2009 - D. Gianola
- 05/06/2009 - F. J. Theis
- 02/06/2009 - M. Babu
- 07/05/2009 - J. Eyzaguirre
- 22/04/2009 - E. Bullinger
- 08/04/2009 - F. Francis
- 04/03/2009 - Kick-off
G-quadruplex nucleic acid structures
Valérie Gabelica (Mass Spectrometry Laboratory)
Date and place: Thursday November 19th, 12:30 pm at amphi Roksam (CHU, B35)
DNA, the repository of genetic information, is found in chromosomes mostly in the form of a Watson-Crick double helix. However, several other types of nucleic acid structures also exist, depending on the sequence and on the environment. G-quadruplexes (G4s) are particular nucleic acid structures which can form when four series of guanines self-assemble into a quadruple helix. Firstly, from a biological point of view, there is accumulating evidence that G4 structures can form in vivo at specific locations in the genome and in RNA, and play a role in gene expression, mutagenesis and disease. Because of their peculiar structures, G4's constitute privileged targets for the development of novel therapeutic molecules. Furthermore, from a chemical point of view, the G4 motif allows the construction of novel supramolecular nano-assemblies. We will show how native mass spectrometry (the analysis of intact non-covalent complexes by mass spectrometry) provides unique insight into the G4 structures, their formation mechanisms, and their interactions with binding partners.