PRE Detector : Prokaryotic Regulatory Elements Detector
In the post-genomic area, the prediction of transcription factor regulons
by position weight matrix-based programmes is a powerful approach to
decipher biological pathways and to modelize regulatory networks in
bacteria. The main difficulty once a regulon prediction is available is to
estimate its reliability prior to start expensive experimental validations
and therefore trying to find a way how to identify true positive hits from
an endless list of potential target genes of a regulatory protein. Here we
introduce PREDetector (Prokaryotic Regulatory Elements Detector), a tool
developed for predicting regulons of DNA-binding proteins in bacterial
genomes that, beside the automatic prediction, scoring and positioning of
potential binding sites and their respective target genes in annotated
bacterial genomes, it also provides an easy way to estimate the thresholds
where to find reliable possible new target genes.
Please cite the following reference when you publish results based on PREDetector searches:
Hiard S, Maree R, Colson S, Hoskisson PA, Titgemeyer F, van Wezel GP, Joris B, Wehenkel L, Rigali S. (2007).
PREDetector: A new tool to identify regulatory elements in bacterial genomes.
Biochem Biophys Res Commun. 357(4):861-4.
Send your comments to Samuel Hiard at S.Hiard@ulg.ac.be
or to Sébastien Rigali at email@example.com
Version 1.1.1 - April 2011
Copyright © 2006 www.cip.ulg.ac.be www.montefiore.ulg.ac.be