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Guillaume Drion - Publications ORBI
de Vrind, V., Scuvée-Moreau, J., Drion, G., Hmaied, C., Philippart, F., Engel, D., & Seutin, V. (2016). Interactions between calcium channels and SK channels in midbrain dopamine neurons and their impact on pacemaker regularity: Contrasting roles of N- and L-type channels. European Journal of Pharmacology, 788, 274-279.
Peer reviewed (verified by ORBi)
Although small-conductance Ca2+-activated K+ (SK) channels and various types of voltage-gated Ca2+ (Cav) channels have been described in midbrain dopaminergic neurons, the nature of their interactions is ...
Canavier, C., Evans, R., Oster, A., Pissadaki, E., Drion, G., Kuznetsov, A., & Gutkin, B. (2016). Implications of cellular models of dopamine neurons for disease. Journal of Neurophysiology.
Peer reviewed (verified by ORBi)
This review addresses the present state of single-cell models of the firing pattern of midbrain dopamine neurons and the insights that can be gained from these models into the underlying mechanisms for ...
Gjorgjieva, J., Drion, G., & Marder, E. (2016). Computational implications of biophysical diversity and multiple timescales in neurons and synapses for circuit performance. Current Opinion in Neurobiology.
Peer reviewed (verified by ORBi)
Despite advances in experimental and theoretical neuroscience, we are still trying to identify key biophysical details that are important for characterizing the operation of brain circuits. Biological ...
Drion, G., O'Leary, T., & Marder, E. (2015, September). Ion channel degeneracy enables robust and tunable neuronal firing rates. Proceedings of the National Academy of Sciences of the United States of America.
Peer reviewed (verified by ORBi)
Firing rate is an important means of encoding information in the nervous system. To reliably encode a wide range of signals, neurons need to achieve a broad range of firing frequencies and to move smoothly ...
Drion, G., Franci, A., Dethier, J., & Sepulchre, R. (2015, February 18). Dynamic Input Conductances Shape Neuronal Spiking. eNeuro.
Peer reviewed
Assessing the role of biophysical parameter variations in neuronal activity is critical to the understanding of modulation, robustness and homeostasis of neuronal signaling. The paper proposes that this ...
Dethier, J.* , Drion, G.* , Franci, & Sepulchre, R. (2015). A positive feedback at the cellular level promotes robustness and modulation at the circuit level. Journal of Neurophysiology.
Peer reviewed (verified by ORBi)
This article highlights the role of a positive feedback gating mechanism at the cellular level in the robustness and modulation properties of rhythmic activities at the circuit level. The results are presented ...
* These authors have contributed equally to this work.
Dethier, J., Drion, G., & Sepulchre, R. (2014, November 16). Contrasting the role of Ih and ICaT currents in post-inhibitory rebound mechanisms in reciprocal-inhibitory networks. Poster session presented at Society for Neuroscience 2014, Washington, DC, USA.
Peer reviewed
Models with reciprocal inhibition are ubiquitous in the literature. For instance, common rhythmic motor behaviors produced by central pattern generators (CPGs) involve half-center oscillators, which consist of ...
Franci, A., Drion, G., & Sepulchre, R. (2014). Modeling the Modulation of Neuronal Bursting: A Singularity Theory Approach. SIAM Journal on Applied Dynamical Systems, 13(2), 798-829.
Peer reviewed (verified by ORBi)
Exploiting the specific structure of neuron conductance-based models, the paper investigates the mathematical modeling of neuronal bursting modulation. The proposed approach combines singularity theory and ...
Dethier, J., Drion, G., Franci, A., & Sepulchre, R. (2013, June). Oscillations in the basal ganglia: illustration of a cellular effect at the network level. Poster session presented at Interdisciplinary Symposium on Signals and Systems for Medical Applications, Paris, France.
Parkinson’s disease (PD) is a neuro-degenerative pathology affecting the basal ganglia (BG), a set of small subcortical nervous system nuclei. The hallmark of the disease is a dopaminergic denervation of the ...
Dethier, J., Drion, G., Franci, A., & Sepulchre, R. (2013, March 26). Impacts of a unicellular mechanism on network behaviors. Paper presented at 32nd Benelux Meeting on Systems and Control, Houffalize, Belgium.
Parkinson’s disease (PD) is a neurodegenerative disorder af- fecting the basal ganglia (BG), a set of small subcortical nervous system nuclei. The hallmark of the disease is a dopaminergic denervation of the ...
Drion, G. (2013). Regulation of Excitability, Pacemaking, and Bursting: Insights from Dopamine Neuron Electrophysiology. Unpublished doctoral thesis, Université de Liège, ​Liège, ​​Belgique.
The present thesis attempts to extract the dynamical mechanisms underlying neuronal excitability and its regulation, through the use of experimental and mathematical techniques. In particular, tools of ...
Franci, A.* , Drion, G.* , Seutin, V., & Sepulchre, R. (2013). A Balance Equation Determines a Switch in Neuronal Excitability. PLoS Computational Biology, 9, 1003040.
Peer reviewed (verified by ORBi)
We use the qualitative insight of a planar neuronal phase portrait to detect an excitability switch in arbitrary conductance-based models from a simple mathematical condition. The condition expresses a balance ...
* These authors have contributed equally to this work.
Drion, G.* , Franci, A.* , Seutin, V., & Sepulchre, R. (2012). A novel phase portrait for neuronal excitability. PLoS ONE, 7(8).
Peer reviewed (verified by ORBi)
Fifty years ago, FitzHugh introduced a phase portrait that became famous for a twofold reason: it captured in a physiological way the qualitative behavior of Hodgkin-Huxley model and it revealed the power of ...
* These authors have contributed equally to this work.
Drion, G., Sepulchre, R., & Seutin, V. (2012). Mitochondrion- and endoplasmic reticulum-induced SK channel dysregulation as a potential origin of the selective neurodegeneration in Parkinson’s disease. In P., Wellstead & M., Cloutier (Eds.), The Systems Biology of Parkinson's Disease. Springer.
Peer reviewed
Mitochondrial dysfunction and metabolic issues are known to have strong implications in the pathogenesis of Parkinson’s disease (PD). But it is also known that the neuronal loss leading to PD symptoms is ...
Franci, A.* , Drion, G.* , & Sepulchre, R. (2012). An Organizing Center in a Planar Model of Neuronal Excitability. SIAM Journal on Applied Dynamical Systems, 11(4), 1698-1722.
Peer reviewed (verified by ORBi)
The paper studies the excitability properties of a generalized FitzHugh-Nagumo model. The model differs from the purely competitive FitzHugh-Nagumo model in that it accounts for the effect of cooperative ...
* These authors have contributed equally to this work.