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François Van Lishout - Publications ORBI
Van Lishout, F. (2016). An efficient and flexible software tool for genome-wide association interaction studies. Unpublished doctoral thesis, Université de Liège, ​Liège, ​​Belgique.
Humans are made up of approximately 3.2 billion base pairs, out of which about 62 million can vary from one individual to another. These particular base pairs are called single nucleotide polymorphisms (SNPs ...
Van Lishout, F., Gadaleta, F., Moore, J. H., Wehenkel, L., & Van Steen, K. (2015). gammaMAXT: a fast multiple-testing correction algorithm. BioData Mining, 8(36).
Peer reviewed (verified by ORBi)
Background: The purpose of the maxT algorithm is to provide a significance test algorithm that controls the family-wise error rate (FWER) during simultaneous hypothesis testing. However, the requirements in ...
Van Lishout, F., Gadaleta, F., Moore, J. H., Wehenkel, L., & Van Steen, K. (2014). gammaMAXT: a fast multiple-testing correction algorithm. ERCIM 2014 Abstract Book (pp. 47).
Peer reviewed
The purpose of the maxT algorithm (1993) is to control the family-wise error rate (FWER) when assessing significance of multiple tests jointly. However, the requirements in terms of computing time and memory ...
Van Lishout, F., Mahachie John, J., Gusareva, E., Urrea, V., Cleynen, I., Theatre, E., Charloteaux, B., Calle, M. L., Wehenkel, L., & Van Steen, K. (2013). An efficient algorithm to perform multiple testing in epistasis screening. BMC Bioinformatics, 14, 138.
Peer reviewed (verified by ORBi)
Background: Research in epistasis or gene-gene interaction detection for human complex traits has grown over the last few years. It has been marked by promising methodological developments, improved ...
Van Lishout, F., Vens, C., Urrea, V., Calle, M. L., Wehenkel, L., & Van Steen, K. (2012, December 03). Survival analysis: finding relevant epistatic SNP pairs using Model- Based Multifactor Dimensionality Reduction. Paper presented at 5th International Conference of the ERCIM WG on COMPUTING & STATISTICS, Oviedo, Spain.
Peer reviewed
Analyzing the combined effects of genes (and/or environmental factors) on the development of complex diseases is quite challenging, both from the statistical and computational perspective, even using a ...
Mahachie John, J., Cattaert, T., Van Lishout, F., Gusareva, E., & Van Steen, K. (2012, January 05). Lower-Order Effects Adjustment in Quantitative Traits Model-Based Multifactor Dimensionality Reduction. PLoS ONE.
Peer reviewed (verified by ORBi)
Identifying gene-gene interactions or gene-environment interactions in studies of human complex diseases remains a big challenge in genetic epidemiology. An additional challenge, often forgotten, is to ...
Mahachie John, J., Gusareva, E., Van Lishout, F., & Van Steen, K. (2011, September 19). A robustness study to investigate the performance of parametric and non-parametric tests used in Model-Based Multifactor Dimensionality Reduction Epistasis Detection. Poster session presented at 20th Annual IGES Conference, Heidelberg, Germany.
Peer reviewed
Model-Based Multifactor Dimensionality Reduction (MB-MDR) is data mining technique to identify gene-gene interactions among 1000nds of SNPs in a fast way, without making assumptions about the mode of genetic ...
Mahachie John, J., Van Lishout, F., & Van Steen, K. (2011). Model-Based Multifactor Dimensionality Reduction to detect epistasis for quantitative traits in the presence of error-free and noisy data. European Journal of Human Genetics, 19, 696-703.
Peer reviewed (verified by ORBi)
Detecting gene-gene interactions or epistasis in studies of human complex diseases is a big challenge in the area of epidemiology. To address this problem, several methods have been developed, mainly in the ...
Van Lishout, F., Chaslot, G., & Uiterwijk, J. W. H. M. (2007). Monte-Carlo Tree Search in Backgammon.
Peer reviewed
Monte-Carlo Tree Search is a new method which has been applied successfully to many games. However, it has never been tested on two-player perfect-information games with a chance factor. Backgam- mon is the ...
Van Lishout, F. (2006). Single-player games: introduction to a new solving method. Unpublished DEA/DES thesis, University of Liège, ​Liège, ​​Belgium.
In many games, the machine has become stronger than the best human players. Machines have already beaten the human World Champion in famous games like Checkers, Chess, Scrabble and Othello. However, mankind ...